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Publications

  1. Sleigh J.N., Mattedi F., Richter S., Annuario E., Ng K., Steinmark I.E., Ivanova I., Darabán I.L., Joshi P.P., Rhymes E.R., Awale S., Yahioglu G., Mitchell J.C., Suhling K., Schiavo G., Vagnoni A. (2024) Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons. Aging Cell. PubMed link, bioRxiv link.
  2. Giamogante F., Barazzuol B., Maiorca F., Poggio E., Esposito A., Masato A., Napolitano G., Vagnoni A., Calì T., Brini M. (2024) A SPLICS reporter reveals α-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation. Nat Commun. PubMed link.
  3. Mattedi F., Lloyds-Morris E., Hirth F., Vagnoni A. (2023) Optogenetic cleavage of the Miro GTPase reveals the direct consequences of real-time loss of function in Drosophila. PLoS Biol. PubMed link, bioRxiv link.
  4. Granat L., Ranson D., Hamer E., Chakrabarty R.P., Mattedi F., Fort-Aznar L., Hirth F., Sweeney S.T., Vagnoni A., Chandel N.S., Bateman J.M. (2023) Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency. PLoS Genet. PubMed link, bioRxiv link.
  5. Maddison D.C., Mattedi F., Vagnoni A., Smith G.A. (2022) Analysis of Mitochondrial Dynamics in Adult Drosophila Axons. Cold Spring Harb Protoc. Pubmed link.
  6. Maddison D.C., Mattedi F., Vagnoni A., Smith G.A. (2022) Clonal Imaging of Mitochondria in the Dissected Fly Wing. Cold Spring Harb Protoc. Pubmed link.
  7. Mattedi F., Maddison D.C., Smith G.A., Vagnoni A. (2022) Live Imaging of Mitochondria in the Intact Fly Wing. Cold Spring Harb Protoc. Pubmed link.
  8. Hewitt V.L., Miller-Fleming L., Twyning M.J., Andreazza S., Mattedi F., Prudent J., Polleux F., Vagnoni A., Whitworth A.J. (2022) Decreasing pdzd8-mediated mito-ER contacts improves organismal fitness and mitigates Aβ42 toxicity. Life Science Alliance, 5:e202201531. Pubmed link.
  9. Mattedi F., Chennell G., Vagnoni A. (2022) Detailed imaging of mitochondrial transport and precise manipulation of mitochondrial function with genetically-encoded photosensitizers in adult Drosophila neurons. Methods in Molecular Biology. 2431:385-407. Pubmed link, Research Square link.
  10. Annuario E., Ng K., Vagnoni A. (2022) High-resolution imaging of mitochondria and mitochondrial nucleoids in differentiated SH-SY5Y cells. Methods in Molecular Biology. 2431:291-310. Pubmed link, Research Square link.
  11. Morotz G.M., Glennon E.B., Greig J., Lau D.H.W., Bhembre N., Mattedi F., Muschalik N., Noble W., Vagnoni A.*, Miller C.C.* (2019) Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein. Acta Neuropathologica Communications, 7:200. Pubmed link.
  12. Mattedi F. and Vagnoni A. (2019) Temporal control of axonal transport: the extreme case of organismal ageing. Frontiers in Cellular Neuroscience, 13:393. Pubmed link.
  13. Morotz G.M., Glennon E.B., Gomez-Suaga P., Lau D.H.W., Robinson E.D., Sedlak E., Vagnoni A., Noble W., Miller C. (2019) LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains. Acta Neuropathologica Communications, 7:73. Pubmed link.
  14. Vagnoni A.*, Bullock S.L.* (2018) A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Ageing Drosophila neurons. Current Biology, 28:1265-1272. Pubmed link.
  15. Sleigh J.N., Vagnoni A., Twelvetrees A.E., Schiavo G. (2017) Methodological advances in imaging intravital axonal transport. F1000Research, 6:200. Pubmed link.
  16. Vagnoni A.*, Bullock S.L.* (2016) A simple method for imaging axonal transport in ageing neurons using the adult Drosophila wing. Nature Protocols, 11:1711-1723. Pubmed link.
  17. Vagnoni A., Hoffmann P.C., Bullock S.L. (2016) Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons. Journal of Cell Science, 129:178-190. Pubmed link.
  18. Vagnoni A., Glennon E.B., Perkinton M.S., Gray E.H., Noble W., Miller C.C. (2013) Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production. Human Molecular Genetics, 22:4646-4652. Pubmed link.
  19. Vagnoni A., Perkinton M.S., Gray E.H., Francis P.T., Noble W., Miller C.C. (2012) Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production. Human Molecular Genetics, 21:2845-2854. Pubmed link.
  20. Morotz G.M., De Vos K.J., Vagnoni A., Ackerley S., Shaw C.E., Miller C.C. (2012) Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria. Human Molecular Genetics, 21:1979-1988. Pubmed link.
  21. Manser C., Vagnoni A., Guillot F., Davies J., Miller C.C. (2012) Cdk5/p35 phosphorylates lemur tyrosine kinase-2 to regulate protein phosphatase-1C phosphorylation and activity. Journal of Neurochemistry, 121:343-348. Pubmed link.
  22. Manser C., Guillot F., Vagnoni A., Davies J., Lau K-F., McLoughlin D.M., De Vos K.J., Miller C.C. (2011) Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo. Oncogene, 31:2773-2782. Pubmed link.
  23. Vagnoni A., Rodriguez L., Manser C., De Vos K.J., Miller C.C. (2011) Phosphorylation of kinesin light chain-1 at serine 460 modulates binding and trafficking of calsyntenin-1. Journal of Cell Science, 124:1032-1042. Pubmed link.
  24. Stevenson A., Yates D.M., Manser C., De Vos K.J., Vagnoni A., Leigh P. N., McLoughlin D.M., and Miller C.C. (2009) Riluzole protects against glutamate-induced slowing of neurofilament axonal transport. Neuroscience Letters, 454:161-164. Pubmed link.

* denotes co-corresponding author/lead contact