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Publications

  1. Mattedi F., Lloyds-Morris E., Hirth F., Vagnoni A. (2022) Optogenetic Miro cleavage reveals direct consequences of real-time loss of function in Drosophila. bioRxiv, doi: https://doi.org/10.1101/2022.10.01.510462. bioRxiv link.
  2. Granat L., Ranson D., Hamer E., Chakrabarty R.P., Mattedi F., Fort-Aznar L., Hirth F., Sweeney S.T., Vagnoni A., Chandel N.S., Bateman J.M. (2022) Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency. bioRxiv, doi: https://doi.org/10.1101/2022.09.22.509020. bioRxiv link.
  3. Maddison D.C., Mattedi F., Vagnoni A., Smith G.A. (2022) Analysis of Mitochondrial Dynamics in Adult Drosophila Axons. Cold Spring Harb Protoc., doi: 10.1101/pdb.top107819. Pubmed link.
  4. Maddison D.C., Mattedi F., Vagnoni A., Smith G.A. (2022) Clonal Imaging of Mitochondria in the Dissected Fly Wing. Cold Spring Harb Protoc., doi: 10.1101/pdb.prot108051. Pubmed link.
  5. Mattedi F., Maddison D.C., Smith G.A., Vagnoni A. (2022) Live Imaging of Mitochondria in the Intact Fly Wing. Cold Spring Harb Protoc., doi: 10.1101/pdb.prot108052. Pubmed link.
  6. Hewitt V.L., Miller-Fleming L., Twyning M.J., Andreazza S., Mattedi F., Prudent J., Polleux F., Vagnoni A., Whitworth A.J. (2022) Decreasing pdzd8-mediated mito-ER contacts improves organismal fitness and mitigates Aβ42 toxicity. Life Science Alliance, 5:e202201531. Pubmed link.
  7. Mattedi F., Chennell G., Vagnoni A. (2022) Detailed imaging of mitochondrial transport and precise manipulation of mitochondrial function with genetically-encoded photosensitizers in adult Drosophila neurons. Methods in Molecular Biology. 2431:385-407. Pubmed link.
  8. Annuario E., Ng K., Vagnoni A. (2022) High-resolution imaging of mitochondria and mitochondrial nucleoids in differentiated SH-SY5Y cells. Methods in Molecular Biology. 2431:291-310. Pubmed link.
  9. Morotz G.M., Glennon E.B., Greig J., Lau D.H.W., Bhembre N., Mattedi F., Muschalik N., Noble W., Vagnoni A.*, Miller C.C.* (2019) Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein. Acta Neuropathologica Communications, 7:200. Pubmed link.
  10. Mattedi F. and Vagnoni A. (2019) Temporal control of axonal transport: the extreme case of organismal ageing. Frontiers in Cellular Neuroscience, 13:393. Pubmed link.
  11. Morotz G.M., Glennon E.B., Gomez-Suaga P., Lau D.H.W., Robinson E.D., Sedlak E., Vagnoni A., Noble W., Miller C. (2019) LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains. Acta Neuropathologica Communications, 7:73. Pubmed link.
  12. Vagnoni A.*, Bullock S.L.* (2018) A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Ageing Drosophila neurons. Current Biology, 28:1265-1272. Pubmed link.
  13. Sleigh J.N., Vagnoni A., Twelvetrees A.E., Schiavo G. (2017) Methodological advances in imaging intravital axonal transport. F1000Research, 6:200. Pubmed link.
  14. Vagnoni A.*, Bullock S.L.* (2016) A simple method for imaging axonal transport in ageing neurons using the adult Drosophila wing. Nature Protocols, 11:1711-1723. Pubmed link.
  15. Vagnoni A., Hoffmann P.C., Bullock S.L. (2016) Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons. Journal of Cell Science, 129:178-190. Pubmed link.
  16. Vagnoni A., Glennon E.B., Perkinton M.S., Gray E.H., Noble W., Miller C.C. (2013) Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production. Human Molecular Genetics, 22:4646-4652. Pubmed link.
  17. Vagnoni A., Perkinton M.S., Gray E.H., Francis P.T., Noble W., Miller C.C. (2012) Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production. Human Molecular Genetics, 21:2845-2854. Pubmed link.
  18. Morotz G.M., De Vos K.J., Vagnoni A., Ackerley S., Shaw C.E., Miller C.C. (2012) Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria. Human Molecular Genetics, 21:1979-1988. Pubmed link.
  19. Manser C., Vagnoni A., Guillot F., Davies J., Miller C.C. (2012) Cdk5/p35 phosphorylates lemur tyrosine kinase-2 to regulate protein phosphatase-1C phosphorylation and activity. Journal of Neurochemistry, 121:343-348. Pubmed link.
  20. Manser C., Guillot F., Vagnoni A., Davies J., Lau K-F., McLoughlin D.M., De Vos K.J., Miller C.C. (2011) Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo. Oncogene, 31:2773-2782. Pubmed link.
  21. Vagnoni A., Rodriguez L., Manser C., De Vos K.J., Miller C.C. (2011) Phosphorylation of kinesin light chain-1 at serine 460 modulates binding and trafficking of calsyntenin-1. Journal of Cell Science, 124:1032-1042. Pubmed link.
  22. Stevenson A., Yates D.M., Manser C., De Vos K.J., Vagnoni A., Leigh P. N., McLoughlin D.M., and Miller C.C. (2009) Riluzole protects against glutamate-induced slowing of neurofilament axonal transport. Neuroscience Letters, 454:161-164. Pubmed link.

* denotes co-corresponding author/lead contact