Welcome!

Publications

  1. Morotz G.M., Glennon E.B., Greig J., Lau D.H.W., Bhembre N., Mattedi F., Muschalik N., Noble W., Vagnoni A.*, Miller C.C.* (2019) Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein. Acta Neuropathologica Communications, 7:200. Pubmed Link.
  2. Mattedi F. and Vagnoni A. (2019) Temporal control of axonal transport: the extreme case of organismal ageing. Frontiers in Cellular Neuroscience, 13:393. Pubmed link.
  3. Morotz G.M., Glennon E.B., Gomez-Suaga P., Lau D.H.W., Robinson E.D., Sedlak E., Vagnoni A., Noble W., Miller C. (2019) LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains. Acta Neuropathologica Communications, 7:73. Pubmed link.
  4. Vagnoni A.*, Bullock S.L.* (2018) A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Ageing Drosophila neurons. Current Biology, 28:1265-1272. Pubmed link.
  5. Sleigh J.N., Vagnoni A., Twelvetrees A.E., Schiavo G. (2017) Methodological advances in imaging intravital axonal transport. F1000Research, 6:200. Pubmed link.
  6. Vagnoni A.*, Bullock S.L.* (2016) A simple method for imaging axonal transport in ageing neurons using the adult Drosophila wing. Nature Protocols, 11:1711-1723Pubmed link.
  7. Vagnoni A., Hoffmann P.C., Bullock S.L. (2016) Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons. Journal of Cell Science, 129:178-190. Pubmed link.
  8. Vagnoni A., Glennon E.B., Perkinton M.S., Gray E.H., Noble W., Miller C.C. (2013) Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production. Human Molecular Genetics, 22:4646-4652. Pubmed link.
  9. Vagnoni A., Perkinton M.S., Gray E.H., Francis P.T., Noble W., Miller C.C. (2012) Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production. Human Molecular Genetics, 21:2845-2854Pubmed link.
  10. Morotz G.M., De Vos K.J., Vagnoni A., Ackerley S., Shaw C.E., Miller C.C. (2012) Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria. Human Molecular Genetics, 21:1979-1988. Pubmed link.
  11. Manser C., Vagnoni A., Guillot F., Davies J., Miller C.C. (2012) Cdk5/p35 phosphorylates lemur tyrosine kinase-2 to regulate protein phosphatase-1C phosphorylation and activity. Journal of Neurochemistry, 121:343-348. Pubmed link.
  12. Manser C., Guillot F., Vagnoni A., Davies J., Lau K-F., McLoughlin D.M., De Vos K.J., Miller C.C. (2011) Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo. Oncogene, 31:2773-2782. Pubmed link.
  13. Vagnoni A., Rodriguez L., Manser C., De Vos K.J., Miller C.C. (2011) Phosphorylation of kinesin light chain-1 at serine 460 modulates binding and trafficking of calsyntenin-1. Journal of Cell Science, 124:1032-1042. Pubmed link.
  14. Stevenson A., Yates D.M., Manser C., De Vos K.J., Vagnoni A., Leigh P. N., McLoughlin D.M., and Miller C.C. (2009) Riluzole protects against glutamate-induced slowing of neurofilament axonal transport. Neuroscience Letters, 454:161-164. Pubmed link.

* denotes co-corresponding author/lead contact